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A man deliberately drove into bicyclists and pedestrians in a bike path in Lower Manhattan, killing at least eight people and injuring more than one dozen in an act of terrorism, New York City Mayor Bill de Blasio, D, said Tuesday.

"This is a very painful day in our city," de Blasio said at a news conference. "Based on the information we had at this moment this was an act of terror, a particularly cowardly act of terror aimed at innocent civilians."

At the news conference, New York Police Department Commissioner James O'Neill said that at around 3:05 p.m., a 29-year-old male driving a rented Home Depot pickup truck entered the West Side Highway bike path, striking bicyclists and pedestrians as he drove southbound. He collided with a bus, injuring two adults and two children inside.

The suspect then "exited the vehicle brandishing two handguns," O'Neill said. A paint ball gun and a pellet gun were later recovered at the scene.

A police officer confronted the suspect and shot him in the abdomen, wounding him, O'Neill said.

A Home Depot spokesman confirmed that a rental truck from the company was involved and said they were cooperating with authorities.

President Trump responded to the attack on Twitter, saying it "looks like another attack by a very sick and deranged person."

Press secretary Sarah Huckabee Sanders said Trump has been briefed on the incident by Chief of Staff Kelly and will be continually updated as more details are known.

"Our Thoughts and prayers are with all those affected," Sanders said.

Though the Islamic State - a militant group that regularly claims responsibility for attacks around the world - did not immediately take responsibility for the New York attack, its supporters celebrated it in online postings, according to SITE Intelligence Group, which monitors extremist activity.

Greg Ahl was driving south on 12th Avenue when he passed "crushed bikes and bodies all along the bike path." He said the suspect must have just driven down the path since "nobody had even stepped up to help [the bikers] yet."

Ahl, of Bay Ridge, Brooklyn, estimated seeing 30 crushed bicycles around 3:15 with "parts everywhere" that "looked like they had been run over."

He said that a pedestrian on the street told him a white pickup truck had just driven south through the bicycle lane.

"After I saw more than a dozen crushed bicycles, I realized what it was," Ahl said.

Officials flooded to the scene after the first reports of carnage that erupted on the west side of Manhattan, not far from Stuyvesant High School and the World Trade Center site.

De Blasio and New York Gov. Andrew Cuomo, D, arrived in the area Tuesday afternoon, where they were briefed on what happened alongside James O'Neill, the New York police commissioner.

After taking the suspected attacker into custody, police said they were not seeking anyone else in relation to the incident.

A fire department spokesman on Tuesday that people were "being treated and evaluated at the scene," which he described as "a pretty lengthy scene." Police in New York urged people to avoid a stretch of West Street extending more than a mile along the west side of Manhattan.

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